DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le X). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.
Second generation of Fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin / M. Andreini, D. Doknic, I. Sutkeviciute, J.J. Reina Martín, J. Duan, E. Chabrol, M. Thepaut, E. Moroni, F. Doro, L. Belvisi, J. Rojo, J. Weiser, F. Fieschi, A. Bernardi. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 9:16(2011), pp. 5778-5786.
|Titolo:||Second generation of Fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin|
ANDREINI, MANUEL (Primo)
DOKNIC, DANIELA (Secondo)
BERNARDI, ANNA (Ultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1039/C1OB05573A|
|Appare nelle tipologie:||01 - Articolo su periodico|