Second generation of Fucose-based  DC-SIGN ligands : affinity improvement and specificity versus Langerin

Andreini, M.; Doknic, D.; Sutkeviciute, I.; Reina Martín, J.J.; Duan, J.; Chabrol, E.; Thepaut, M.; Moroni, E.; Doro, F.; Belvisi, L.; Rojo, J.; Weiser, J.; Fieschi, F.; Bernardi, A.

doi:10.1039/C1OB05573A

DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le X). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.

Second generation of Fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin / M. Andreini, D. Doknic, I. Sutkeviciute, J.J. Reina Martín, J. Duan, E. Chabrol, M. Thepaut, E. Moroni, F. Doro, L. Belvisi, J. Rojo, J. Weiser, F. Fieschi, A. Bernardi. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 9:16(2011), pp. 5778-5786.

Titolo:	Second generation of Fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin
Autori:	ANDREINI, MANUEL (Primo) DOKNIC, DANIELA (Secondo) I. Sutkeviciute REINA MARTIN, JOSE JUAN J. Duan E. Chabrol M. Thepaut MORONI, ELISABETTA MARIA DORO, FABIO BELVISI, LAURA J. Rojo J. Weiser F. Fieschi BERNARDI, ANNA (Ultimo) mostra contributor esterni nascondi contributor esterni
Settore Scientifico Disciplinare:	Settore CHIM/06 - Chimica Organica
Data di pubblicazione:	2011
Rivista:	ORGANIC & BIOMOLECULAR CHEMISTRY
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1039/C1OB05573A
Appare nelle tipologie:	01 - Articolo su periodico

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