Gold nanoparticles stabilized by nucleobases, nucleosides and nucleotides S. Avvakumova, Milano/I, F. Porta, Milano/I, G. Scari, Milano/I Dr. Svetlana Avvakumova, University of Milan, Dip. Chimica Inorganica Metall. Anal., L. Malatesta, Via Venezian 21, 20133 Milano, Italy Today gold nanoparticles (AuNPs) have become an important biomedical tool in cancer research. The presence of a negative charge on the surface of AuNPs helps to modify the surface of AuNPs by binding with several biomolecules. It is well established that capped AuNPs are biocompatible and non-toxic allowing their use in cancer treatment . Nucleobases, nucleosides and nucleotides, used in this work, were among the first chemotherapeutic agents introduced for the medical treatment of cancer. These agents behave as antimetabolites and interact with a large number of intracellular targets. Biocompatible gold nanoparticles have been synthesized by reduction of NaAuCl4 aqueous solution by sodium borohydride as reducing agent. Adenine, adenosine, guanine, guanosine, cytosine, cytidine, thymine, guanosine 5’- monophosphate and cytidine 5’-monophosphate were used as stabilising agents. Au:stabiliser:NaBH4 molar ratios have been set up for obtaining red stable sols constituted by spherical gold nanoparticles with mean diameters in the 2-10 nm range. Reaction course was followed by UV-vis spectroscopy for studying the kinetic of reaction and plasmon peaks were found in the range of 513-530 nm. The colloids obtained were characterized by spectroscopic, microscopic and crystallographic methods (1H NMR, ATR-FTIR, XRD and TEM) studying the ligand interaction with the surface of gold nanoparticles. ATR-FTIR and 1H-NMR studies highlighted that the binding of ligands with the metallic surface dipends on the structure of molecules (nucleobases, nucleosides or nucleotides). Literature:  C. M. Galmarini, J. R. Mackey, C. Dumontet, The Lancet Oncology, 2002, Vol 3, p. 415.
|Titolo:||Gold nanoparticles stabilised by GGC peptide terminated with a RDG motif|
|Data di pubblicazione:||29-ago-2010|
|Settore Scientifico Disciplinare:||Settore CHIM/03 - Chimica Generale e Inorganica|
|Enti collegati al convegno:||European Association for Chemical and Molecular Sciences|
|Citazione:||Gold nanoparticles stabilised by GGC peptide terminated with a RDG motif / F. Porta, S. Avvakumova, G. Scarì. ((Intervento presentato al 3. convegno EuCheMS Chemistry Congress tenutosi a Nürnberg nel 2010.|
|Appare nelle tipologie:||14 - Intervento a convegno non pubblicato|