In S. cerevisiae, the Ras/cAMP/PKA pathway is involved in the regulation of cell growth and proliferation in response to nutritional sensing and stress conditions. The pathway is tightly regulated by multiple feedback loops that can lead the second messenger cAMP to oscillatory regimes. In this paper we analyze the dynamics of cAMP by performing stochastic simulations of a mechanistic model of the Ras/cAMP/PKA pathway, to consider the effects of the deletion of phosphodiesterases (the enzymes catalyzing the degradation of cAMP, which represent the major negative feedback in this pathway) and the role of the intracellular ratio of guanine nucleotides (GTP/GDP).

Investigating oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiae: the role of feedback control mechanisms / D. Besozzi, P. Cazzaniga, D. Pescini, G. Mauri, S. Colombo, E. Martegani - In: Eighth international workshop on computational systems biology, WCSB 2011, june 6-8, 2011, Zürich, Switzerland / [a cura di] H. Koeppl, J. Acimovic, J. Kesseli, T. Mäki-Marttunen, A. Larjo, O. Yli-Harja. - Tampere : Tampere International Center for Signal Processing., 2011. - ISBN 9789521525919. - pp. 33-36 (( Intervento presentato al 8th. convegno International Workshop on Computational Systems Biology, WCSB 2011 tenutosi a Zürich, Switzerland nel 2011.

Investigating oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiae: the role of feedback control mechanisms

D. Besozzi;
2011

Abstract

In S. cerevisiae, the Ras/cAMP/PKA pathway is involved in the regulation of cell growth and proliferation in response to nutritional sensing and stress conditions. The pathway is tightly regulated by multiple feedback loops that can lead the second messenger cAMP to oscillatory regimes. In this paper we analyze the dynamics of cAMP by performing stochastic simulations of a mechanistic model of the Ras/cAMP/PKA pathway, to consider the effects of the deletion of phosphodiesterases (the enzymes catalyzing the degradation of cAMP, which represent the major negative feedback in this pathway) and the role of the intracellular ratio of guanine nucleotides (GTP/GDP).
Settore INF/01 - Informatica
Settore BIO/11 - Biologia Molecolare
2011
http://www.wcsb2011.ethz.ch/proc_wcsb2011.pdf
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/161769
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