The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies

Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope / T. Matthias, S. Pfeiffer, C. Selmi, M. Eric Gershwin. - In: CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY. - ISSN 1080-0549. - 38:2-3(2010 Apr), pp. 298-301.

Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope

C. Selmi
Penultimo
;
2010

Abstract

The diagnosis of celiac disease (CD) remains a clinical challenge based on the incomplete specificity and sensitivity rates of current non-invasive tests. Furthermore, histological assessments fail to identify all overt cases and, in particular, do not manifest pathognomonic alterations in silent cases. Accordingly, the majority of CD cases are diagnosed with great delay. Recent research into the pathogenesis of CD, allowed us to identify a neo-antigen that appears to be the most promising serological tool for the detection of anti-tissue transglutaminase as well as anti-gliadin antibodies
sensitivity and specificity ; humans ; transglutaminases ; enzyme-linked immunosorbent assay ; celiac disease ; gliadin ; epitopes
Settore MED/09 - Medicina Interna
Settore MED/16 - Reumatologia
apr-2010
23-lug-2009
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/161603
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