A cross-sectional study was carried out to improve the state of evidence regarding the spectrum of HPV types and HPV-16 LCR variants circulating among men and women infected with HIV-1 in Italy. This study, conducted in 518 HIV-positive subjects (346 males and 172 females), showed a high prevalence of HPV anal infections (88.7%) in men and of cervical infections (65.1%) in women. A wide spectrum of HPV genotypes has been observed, as both single and multiple infections. Low-risk HPV types 6, 11 and 61 were frequently detected. HPV-16 was the prevalent high-risk type. Fourteen different HPV-16 LCR variants were found. Ten belonged to the European lineage (78.7% were detected in Italian subjects and 21.3% in foreign-born, all homo/bisexual men), two to the Asiatic lineage and two to the African-2 lineage. This study underlines the great genotypic heterogeneity characterizing anal and cervical HPV infections and the marked polymorphism of the predominant HPV-16 in this high-risk population in Italy.
Human papillomavirus genotypes and phylogenetic analysis of HPV-16 variants in HIV-1 infected subjects in Italy / TANZI ELISABETTA, AMENDOLA ANTONELLA, BIANCHI SILVIA, M.M. Fasolo, R. Beretta, PARIANI ELENA, ZAPPA ALESSANDRA, FRATI ELENA ROSANNA, G. Orlando. - In: VACCINE. - ISSN 0264-410X. - 27:suppl. 1(2009), pp. A17-A23. ((Intervento presentato al convegno National HPV tenutosi a Genova nel 2008.
|Titolo:||Human papillomavirus genotypes and phylogenetic analysis of HPV-16 variants in HIV-1 infected subjects in Italy|
TANZI, ELISABETTA (Primo)
AMENDOLA, ANTONELLA (Secondo)
FRATI, ELENA ROSANNA (Penultimo)
|Parole Chiave:||Human papillomavirus; HIV-1 positive men and women; HPV-16 LCR variants|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.vaccine.2008.10.091|
|Appare nelle tipologie:||01 - Articolo su periodico|