Synthesis of 1,4-2H-oxazine derivatives was performed by Pd(II)-catalyzed aerobic oxidative cyclization of 3-aza-5-alkenols, prepared from easily available 1,2-amino alcohols. The reaction proceeds in very mild conditions with a simple catalytic system consisting of PdCl2(MeCN)2 in THF at room temperature with molecular oxygen as the sole stoichiometric oxidant.
Intramolecular Oxidative Pd(II)-Catalyzed Alkoxylation of 3-Aza-5-alkenols with O2 as Sole Oxidant: Mild Conditions for the Synthesis of 1,4-Oxazine Derivatives / G. Broggini, E. Beccalli, E. Borsini, A. Fasana, G. Zecchi. - In: SYNLETT. - ISSN 0936-5214. - 2011:2(2011), pp. G31210ST.227-G31210ST.230.
Intramolecular Oxidative Pd(II)-Catalyzed Alkoxylation of 3-Aza-5-alkenols with O2 as Sole Oxidant: Mild Conditions for the Synthesis of 1,4-Oxazine Derivatives
E. BeccalliSecondo
;E. Borsini;
2011
Abstract
Synthesis of 1,4-2H-oxazine derivatives was performed by Pd(II)-catalyzed aerobic oxidative cyclization of 3-aza-5-alkenols, prepared from easily available 1,2-amino alcohols. The reaction proceeds in very mild conditions with a simple catalytic system consisting of PdCl2(MeCN)2 in THF at room temperature with molecular oxygen as the sole stoichiometric oxidant.
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