The use of suitable therapeutic protocols is particularly important when extra-label drugs are used or when physiological parameters are modified, as in the case of the administration of alkaline substances to racehorses. The pharmacokinetics of naproxen (NAP), after both intravenous (iv) and oral administration of 10 mg/kg body weight (BW), was investigated in horses under normal metabolic conditions and in horses whose conditions were modified by the iv administration of 250 mg/kg BW of sodium bicarbonate (NaHCO 3). The hypothesis that blood and consequent urinary alkalization could modify NAP pharmacokinetics was evaluated. Drug quantification was performed on serum and urine using High Performance Liquid Chromatography (HPLC) with ultraviolet-visible detection. Results were also integrated with cycloxygenase (COX)-inhibition published data to suggest an appropriate schedule for NAP dosage in horses. After iv administration, NAP was rapidly distributed (t 1/2α: 0.71 ± 0.43 iv NaHCO 3 and 0.55 ± 0.62 hours No NaHCO 3), whereas its elimination was quite slow (t 1/2β: 6.74 ± 0.41 hours), particularly in iv NaHCO 3 animals (t 1/2β: 8.95 ± 1.37 hours). After oral treatments, NAP was more rapidly absorbed and elimination was slower in iv NaHCO 3 animals (t 1/2λ z: 17.50 ± 6.66 vs. 7.17 ± 0.91 hours). The oral bioavailability of NAP was approximately 87% and 77% in No NaHCO 3 and iv NaHCO 3, respectively. Urinary excretion of the drug as a parent compound was low. The alkalization procedure did not anticipate the elimination of the acidic drug as expected, but it also influenced the absorption of the drug that was administered orally. The dosage scheme of 10 mg/kg BW iv or orally seems to be appropriate to produce an anti-inflammatory effect for 12 to 24 hours.
Pharmacokinetics and effects of alkalization during oral and intravenous administration of naproxen in horses / P.P. Cagnardi, M. Gallo, A. Zonca, S. Carli, R.E. Villa. - In: JOURNAL OF EQUINE VETERINARY SCIENCE. - ISSN 0737-0806. - 31:8(2011 Aug), pp. 456-462.
|Titolo:||Pharmacokinetics and effects of alkalization during oral and intravenous administration of naproxen in horses|
CAGNARDI, PETRA PICO' (Primo)
GALLO, MARTINA (Secondo)
CARLI, SILVANO (Penultimo)
VILLA, ROBERTO EDOARDO (Ultimo)
|Parole Chiave:||Alkalization; Horse; Kinetics; Naproxen; NSAID|
|Settore Scientifico Disciplinare:||Settore VET/07 - Farmacologia e Tossicologia Veterinaria|
|Data di pubblicazione:||ago-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jevs.2011.03.019|
|Appare nelle tipologie:||01 - Articolo su periodico|