The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human-mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts.
DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes / A. Boccia, M. Petrillo, D. di Bernardo, A. Guffanti, F. Mignone, S. Confalonieri, L. Luzi, G. Pesole, G. Paolella, A. Ballabio, S. Banfi. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 33(2005), pp. D505-D510. [10.1093/nar/gki011]
|Titolo:||DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes|
|Settore Scientifico Disciplinare:||Settore INF/01 - Informatica|
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/nar/gki011|
|Appare nelle tipologie:||01 - Articolo su periodico|