Patients with unstable angina have an increased activation of the coagulation system. Aspirin and ticlopidine given in combination may potentiate each other by the combination of different action mechanisms and may reduce the risk of coronary occlusion and clinical instability. Plasma tissue factor (TF) levels collected into the stenotic coronary artery may be an index of TF expression within the vasculature. In 160 patients undergoing angioplasty for a 81+/-5% coronary lesion, we measured TF in blood samples collected from a vein and from the coronary ostium. Immediately after and 10 minutes after the dilation procedures the samples were withdrawn also beyond the lesion. Heparin 150 U/kg was given as an anticoagulant. All patients were pretreated with 250 mg/day of aspirin. One hundred twenty patients were randomly assigned to receive 24, 48, or 72 hours of ticlopidine treatment (250 mg/twice daily). TF levels did not increase during angioplasty but there was a significantly higher TF expression in unstable than in stable patients, irrespective of the invasiveness of debulking procedures. When ticlopidine was given for 72 hours, TF levels were similar to normal laboratory values both in stable and unstable patients. This combined antiplatelet pretreatment may be of benefit in unstable angina patients, with a favorable cost/benefit ratio.

Effect of aspirin and ticlopidine on plasma tissue factor levels in stable an unstable angina pectoris / J. Marco, R.A. Ariens, J. Fajadet, I.E. Bossi, I. Marco, M. Bernies, S.M. Romano, F. Donatelli, G.M. Brambilla, F. Somalvico, D. Mari, L.C. Ventura-Gregorini. - In: THE AMERICAN JOURNAL OF CARDIOLOGY. - ISSN 0002-9149. - 85:5(2000 Mar), pp. 527-531.

Effect of aspirin and ticlopidine on plasma tissue factor levels in stable an unstable angina pectoris

I.E. Bossi;F. Donatelli;F. Somalvico;D. Mari
Penultimo
;
L.C. Ventura-Gregorini
Ultimo
2000

Abstract

Patients with unstable angina have an increased activation of the coagulation system. Aspirin and ticlopidine given in combination may potentiate each other by the combination of different action mechanisms and may reduce the risk of coronary occlusion and clinical instability. Plasma tissue factor (TF) levels collected into the stenotic coronary artery may be an index of TF expression within the vasculature. In 160 patients undergoing angioplasty for a 81+/-5% coronary lesion, we measured TF in blood samples collected from a vein and from the coronary ostium. Immediately after and 10 minutes after the dilation procedures the samples were withdrawn also beyond the lesion. Heparin 150 U/kg was given as an anticoagulant. All patients were pretreated with 250 mg/day of aspirin. One hundred twenty patients were randomly assigned to receive 24, 48, or 72 hours of ticlopidine treatment (250 mg/twice daily). TF levels did not increase during angioplasty but there was a significantly higher TF expression in unstable than in stable patients, irrespective of the invasiveness of debulking procedures. When ticlopidine was given for 72 hours, TF levels were similar to normal laboratory values both in stable and unstable patients. This combined antiplatelet pretreatment may be of benefit in unstable angina patients, with a favorable cost/benefit ratio.
Ticlopidine ; Peptide Hydrolases ; Humans ; Angina Pectoris ; Angioplasty, Balloon, Coronary ; Drug Therapy, Combination ; Aspirin ; Thromboplastin ; Premedication ; Atherectomy, Coronary ; Stents ; Middle Aged ; Platelet Aggregation Inhibitors ; Time Factors ; Angina, Unstable ; Antithrombin III ; Female ; Male
Settore MED/09 - Medicina Interna
mar-2000
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/160683
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