The results of a multicentric therapy protocol for Idiopathic Thrombocytopenic Purpura (ITP) in previously untreated patients are reported. Two different regimens of prednisone (A1: 0.5 mg/kg/day; A2: 1.5 mg/kg/day) were used in the induction phase. One hundred thirty patients (69 adults, 61 children), with a follow-up of almost 6 months, were evaluated. In adults good response to induction therapy was obtained in 30% of patients on schedule A1 and in 34% on schedule A2. In children good response was reached in 62% of cases with schedule A1 and in 81% with schedule A2. The difference in response to induction therapy in children vs. adults is statistically significant (p<0.001), whether the two schedules are considered separately or evaluated together. Anti-platelet, anti-nuclear, anti-smooth muscle, anti-mitochondrial, anti-viral and anti-toxoplasma antibodies were also determined at onset of the disease and after induction treatment. Thirty-two patients (25 adults and 7 children) with refractory ITP were splenectomized, twenty-six of whom had been previously studied for platelet survival and kinetics.
Treatment of idiopathic thrombocytopenic purpura (ITP): results of a multicentric protocol. / M.G. Mazzucconi, M. Francesconi, P. Fidani, G.D. Di Nucci, G.M. Gandolfo, A. Afeltra, C. Masala, M. Di Prima, G. Rocchi, S. Resta, F. Mandelli, F. Grignai, A. Bagnato, C. Almici, B. Comotti, D. Mari, A. Morini, G.G. Nenci, E. Volpe, P. Coser, E. Lanzi, L. Gugliotta, D. Rosati, C. Miano, F. Pericoli Ridolfini. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 70:4(1985), pp. 329-336.
Treatment of idiopathic thrombocytopenic purpura (ITP): results of a multicentric protocol.
D. Mari;
1985
Abstract
The results of a multicentric therapy protocol for Idiopathic Thrombocytopenic Purpura (ITP) in previously untreated patients are reported. Two different regimens of prednisone (A1: 0.5 mg/kg/day; A2: 1.5 mg/kg/day) were used in the induction phase. One hundred thirty patients (69 adults, 61 children), with a follow-up of almost 6 months, were evaluated. In adults good response to induction therapy was obtained in 30% of patients on schedule A1 and in 34% on schedule A2. In children good response was reached in 62% of cases with schedule A1 and in 81% with schedule A2. The difference in response to induction therapy in children vs. adults is statistically significant (p<0.001), whether the two schedules are considered separately or evaluated together. Anti-platelet, anti-nuclear, anti-smooth muscle, anti-mitochondrial, anti-viral and anti-toxoplasma antibodies were also determined at onset of the disease and after induction treatment. Thirty-two patients (25 adults and 7 children) with refractory ITP were splenectomized, twenty-six of whom had been previously studied for platelet survival and kinetics.File | Dimensione | Formato | |
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