Aim of this study was to reconstruct the temporal and spatial phylodynamics of WNV-1a, the genotype to which the majority of European/Mediterranean viral strains belongs, by using sequences retrieved from public databases. WNV-1a isolates segregated into two major clades: the recent West Mediterranean sequences formed a single monophyletic group within clade A. Clade B included sequences from East Mediterranean and America. Phylogeographic analysis suggested that WNV-1a probably originated in sub-Saharan Africa in the early XXth century, and then spread northwards since the late 1970s, via two routes: one crossing Eastern Mediterranean and the other the Western Mediterranean countries. Our data suggest that the circulation of the virus in a given geographical area usually precedes the onset of the outbreak by one year or more, and underline the importance of the spatial–temporal phylodynamics reconstruction in clarifying the recent epidemiology and in setting up an efficient surveillance system for emerging/reemerging zoonosis.

Phylogeography and epidemiological history of West Nile virus genotype 1a in Europe and the Mediterranean basin / G. Zehender, E. Ebranati, F. Bernini, A. Lo Presti, G. Rezza, M. Delogu, M. Galli, M. Ciccozzi. - In: INFECTION GENETICS AND EVOLUTION. - ISSN 1567-1348. - 11:3(2011 Apr), pp. 646-653. [10.1016/j.meegid.2011.02.003]

Phylogeography and epidemiological history of West Nile virus genotype 1a in Europe and the Mediterranean basin

G. Zehender
Primo
;
E. Ebranati
Secondo
;
F. Bernini;M. Galli
Penultimo
;
2011

Abstract

Aim of this study was to reconstruct the temporal and spatial phylodynamics of WNV-1a, the genotype to which the majority of European/Mediterranean viral strains belongs, by using sequences retrieved from public databases. WNV-1a isolates segregated into two major clades: the recent West Mediterranean sequences formed a single monophyletic group within clade A. Clade B included sequences from East Mediterranean and America. Phylogeographic analysis suggested that WNV-1a probably originated in sub-Saharan Africa in the early XXth century, and then spread northwards since the late 1970s, via two routes: one crossing Eastern Mediterranean and the other the Western Mediterranean countries. Our data suggest that the circulation of the virus in a given geographical area usually precedes the onset of the outbreak by one year or more, and underline the importance of the spatial–temporal phylodynamics reconstruction in clarifying the recent epidemiology and in setting up an efficient surveillance system for emerging/reemerging zoonosis.
West Nile virus genotype 1a; spatio temporal phylodynamics; Bayesian phylogeography; WNV 2008/2009 Italian epidemic; migratory birds; Mediterranean WNV
Settore MED/17 - Malattie Infettive
Settore MED/42 - Igiene Generale e Applicata
apr-2011
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/160535
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