Availability of peripheral biomarkers for depression could aid diagnosis and help to predict treatment response. The objective of this work was to analyse the peripheral biomarker response in a gene-environment interaction model of depression. Genetically selected Flinders Sensitive Line (FSL) rats were subjected to maternal separation (MS), since early-life trauma is an important antecedent of depression. An open-ended approach based on a proteomic analysis of serum was combined with the evaluation of depression-associated proteins.
Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression / L. Carboni, S. Becchi, C. Piubelli, A. Mallei, R. Giambelli, M. Razzoli, A.A. Mathé, M. Popoli, E. Domenici. - In: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. - ISSN 0278-5846. - 34:6(2010 Aug 16), pp. 1037-1048. [10.1016/j.pnpbp.2010.05.019]
Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression
A. Mallei;M. PopoliPenultimo
;
2010
Abstract
Availability of peripheral biomarkers for depression could aid diagnosis and help to predict treatment response. The objective of this work was to analyse the peripheral biomarker response in a gene-environment interaction model of depression. Genetically selected Flinders Sensitive Line (FSL) rats were subjected to maternal separation (MS), since early-life trauma is an important antecedent of depression. An open-ended approach based on a proteomic analysis of serum was combined with the evaluation of depression-associated proteins.
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