Aim of this work is the study of abnormalities induced by the triazole triadimefon (FON) administered to pregnant mice at E8, E9, E10, E11 or E12. Pregnant CD-1 mouse were gavaged with FON 500 mg/kg at the selected stages and sacrificed at term and fetuses morphologically examined and processed for visceral and skeletal analysis. Administration of FON on E8, E10-E12 resulted in fetuses with cleft palate (E8 39% and E12 24% representing the peak of sensitivity, in E8 fetuses associated to severe skull basis abnormalities). Other cranial malformations (fusions abnormalities or agenesis of bones) were observed in E8-E10 groups (E8 the most sensitive with 96% of malformed fetuses). Cardiovascular abnormalities were observed in a stage dependent manner at E8-E10 (22.2, 3.8, 7.8%). As far as craniofacial malformation is concerned, we propose that FON acts on two different stages, involved in early and late craniofacial formation.
Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse / F. Di Renzo, M.L. Broccia, E. Giavini, E. Menegola. - In: REPRODUCTIVE TOXICOLOGY. - ISSN 0890-6238. - 31:2(2011), pp. 194-199.
|Titolo:||Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse|
DI RENZO, FRANCESCA (Primo)
BROCCIA, MARIALUISA (Secondo)
GIAVINI, ERMINIO (Penultimo)
MENEGOLA, ELENA (Ultimo)
|Parole Chiave:||Cardiac defects; Cleft palate; Stage-specificity; Teratogenesis; Triadimefon|
|Settore Scientifico Disciplinare:||Settore BIO/06 - Anatomia Comparata e Citologia|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.reprotox.2010.10.011|
|Appare nelle tipologie:||01 - Articolo su periodico|