Purpose: The main prognostic factor of lung cancer patient outcome is clinical stage, a parameter of tumor aggressiveness. Our study was conducted to test whether germ line variations modulate individual differences in clinical stage. Experimental Design: We conducted a case-only genome-wide association study (GWAS) using a 620,901 single-nucleotide polymorphism (SNP) array in a first series of 600 lung adenocarcinoma (ADCA)patients and in a replication series of 317 lung ADCA patients. Results: GWAS identified 54 putatively associated SNPs, 3 of which were confirmed in the replication series. Joint analysis of the two series pointed to 22 statistically associated (P < 0.01) genetic variants that together explained about 20% of the phenotypic variation in clinical staging (P < 2 10 16) and showed a statistically significant difference in overall survival (P ¼ 8.0 10 8). The strongest statistical association was observed at rs10278557 (P ¼ 1.1 10 5), located in the mesenchyme homeobox 2 (MEOX2) gene. Conclusion: These data point to the role of germ line variations involving multiple loci in modulating clinical stage and, therefore, prognosis in lungADCApatients
Multiple genetic loci modulate lung adenocarcinoma clinical staging / E. Frullanti, A. Galvan, F.S. Falvella, G. Manenti, F. Colombo, A. Vannelli, M. Incarbone, M. Alloisio, M. Nosotti, L. Santambrogio, A. Gonzalez-Neira, U. Pastorino, T. Dragani. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - 17:8(2011 Apr), pp. 2410-2416.
|Titolo:||Multiple genetic loci modulate lung adenocarcinoma clinical staging|
|Settore Scientifico Disciplinare:||Settore MED/21 - Chirurgia Toracica|
|Data di pubblicazione:||apr-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1158/1078-0432.CCR-10-2394|
|Appare nelle tipologie:||01 - Articolo su periodico|