Integrin antagonists: Saturation transfer difference (STD) and transferred NOE provided useful information on membrane-bound receptor-ligand interactions in living cells in which the integrin αvβ3 is highly expressed. The epitopes of two cyclic RGD mimics were identified by STD. The different activities of these compounds were interpreted in terms of different binding modes. The experimental evidence was confirmed by docking calculations.

STD and trNOESY NMR Study of Receptor-Ligand Interactions in Living Cancer Cells / D. Potenza, F. Vasile, L. Belvisi, M. Civera, E.M.V. Araldi. - In: CHEMBIOCHEM. - ISSN 1439-4227. - 12:5(2011 Mar 21), pp. 695-699.

STD and trNOESY NMR Study of Receptor-Ligand Interactions in Living Cancer Cells

D. Potenza;F. Vasile;L. Belvisi;M. Civera;E.M.V. Araldi
2011-03-21

Abstract

Integrin antagonists: Saturation transfer difference (STD) and transferred NOE provided useful information on membrane-bound receptor-ligand interactions in living cells in which the integrin αvβ3 is highly expressed. The epitopes of two cyclic RGD mimics were identified by STD. The different activities of these compounds were interpreted in terms of different binding modes. The experimental evidence was confirmed by docking calculations.
living cancer cells ; membrane proteins ; molecular modeling ; protein-ligand interactions ; STD-NMR
Settore CHIM/03 - Chimica Generale e Inorganica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/157638
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