The invention relates to the design of inhibitors of the HIV-1-PR homodimer which do not create resistance, by blocking the folding of single monomers with the help of peptides which attach to highly-conserved sites of the monomers.
A folding inhibitor of HIV-1 Protease as antiviral drug / R.A. Broglia, G. Tiana, D. Provasi.
A folding inhibitor of HIV-1 Protease as antiviral drug
R. A. Broglia;G. Tiana;D. Provasi
2007-03-29
Abstract
The invention relates to the design of inhibitors of the HIV-1-PR homodimer which do not create resistance, by blocking the folding of single monomers with the help of peptides which attach to highly-conserved sites of the monomers.
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