The diagnosis of Amyotrophic lateral sclerosis (ALS) remains clinical with neurophysiological support in absence of specific biomarker(s). The disease is diverse in its presentation, cause, and progression. Treatable mimic syndromes must be excluded before the diagnosis is ascribed: ALS and its variants are recognized by neurologists, but 10% of patients are misdiagnosed. Delays in diagnosis are common. Less than 10% of cases are familial and associated with several interactive genes. The onset of ALS predates development of the clinical symptoms by an unknown interval which may extend several years. Prompt diagnosis, sensitive communication of the diagnosis, involvement of the patient and family, positive care plan, are pre-requisites for the good clinical management of ALS patients.

The diagnosis of Amyotrophic Lateral Sclerosis / V. Silani, S. Messina, B. Poletti, C. Morelli, A. Doretti, N. Ticozzi, L. Maderna. - In: ARCHIVES ITALIENNES DE BIOLOGIE. - ISSN 0003-9829. - 149:1(2011), pp. 5-27.

The diagnosis of Amyotrophic Lateral Sclerosis

V. Silani;B. Poletti;C. Morelli;N. Ticozzi;
2011

Abstract

The diagnosis of Amyotrophic lateral sclerosis (ALS) remains clinical with neurophysiological support in absence of specific biomarker(s). The disease is diverse in its presentation, cause, and progression. Treatable mimic syndromes must be excluded before the diagnosis is ascribed: ALS and its variants are recognized by neurologists, but 10% of patients are misdiagnosed. Delays in diagnosis are common. Less than 10% of cases are familial and associated with several interactive genes. The onset of ALS predates development of the clinical symptoms by an unknown interval which may extend several years. Prompt diagnosis, sensitive communication of the diagnosis, involvement of the patient and family, positive care plan, are pre-requisites for the good clinical management of ALS patients.
Settore MED/26 - Neurologia
Settore M-PSI/08 - Psicologia Clinica
Article (author)
File in questo prodotto:
File Dimensione Formato  
Silani Als Diagnosis Arch It Biol 2011.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 179.44 kB
Formato Adobe PDF
179.44 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/156842
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 25
  • ???jsp.display-item.citation.isi??? 20
social impact