There is increasing clinical, imaging and neurophatological evidence that Amyotrophic lateral sclerosis (ALS) represents a multisystem neurodegenerative disease. Neurodegeneration is not restricted to motor neurons, but also includes parts of the brain other than the motor cortex, especially the prefrontal and/or anterior temporal lobe, that contribute to the clinical syndrome. In some cases an evident dementia that resembles frontotemporal degeneration (FTD) was observed. It is now suggested that ALS and FTD are closely related conditions with overlapping clinical, pathological, radiological, and genetic characteristics. The presence of a frontal dementia in ALS has also crucial practical consequences for management of the patients, whose disorder requires critical life decisions for enteral nutrition and respiratory complications. It is our intent to provide a brief overview of the relationships between ALS and FTD.

Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) / S. Zago, B. Poletti, C. Morelli, A. Doretti, V. Silani. - In: ARCHIVES ITALIENNES DE BIOLOGIE. - ISSN 0003-9829. - 149:1(2011), pp. 39-56.

Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD)

S. Zago;B. Poletti;C. Morelli;V. Silani
2011

Abstract

There is increasing clinical, imaging and neurophatological evidence that Amyotrophic lateral sclerosis (ALS) represents a multisystem neurodegenerative disease. Neurodegeneration is not restricted to motor neurons, but also includes parts of the brain other than the motor cortex, especially the prefrontal and/or anterior temporal lobe, that contribute to the clinical syndrome. In some cases an evident dementia that resembles frontotemporal degeneration (FTD) was observed. It is now suggested that ALS and FTD are closely related conditions with overlapping clinical, pathological, radiological, and genetic characteristics. The presence of a frontal dementia in ALS has also crucial practical consequences for management of the patients, whose disorder requires critical life decisions for enteral nutrition and respiratory complications. It is our intent to provide a brief overview of the relationships between ALS and FTD.
ALS; FTD; ALS-FTD syndrome
Settore MED/26 - Neurologia
Settore M-PSI/08 - Psicologia Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/156841
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