Tramadol is a synthetic codeine analogue used as an analgesic in human and veterinary medicine, but not approved for use in cats. Tramadol (2. mg/kg) was administered intravenously (IV) as preoperative analgesic in 12 cats (6 males) undergoing surgical gonadectomy. The pharmacokinetic profile of the drug and its O-desmethyl metabolite were determined in 8 animals (4 males), while intraoperative effects and postoperative analgesia, estimated by subjective pain score (0-24), were evaluated in all. Mean intraoperative isoflurane consumption was reduced, but hypoventilation was not observed. Sex-related differences were not observed, particularly in terms of postoperative analgesia: rescue analgesic was never administered. Concentrations of the active O-desmethyl metabolite were persistently high in all the animals. Considering the results obtained in this study, tramadol, at the dose of 2. mg/kg IV, did not produce any evident intraoperative cardiorespiratory side effects and with additional investigation may prove to be an appropriate intraoperative analgesic in cats undergoing gonadectomy.
Pharmacokinetics, intraoperative effect and postoperative analgesia of tramadol in cats / P.P. Cagnardi, R.E. Villa, A. Zonca, M. Gallo, M. Beccaglia, G.C. Luvoni, E. Vettorato, S. Carli, D. Fonda, G. Ravasio. - In: RESEARCH IN VETERINARY SCIENCE. - ISSN 0034-5288. - 90:3(2011 Jun), pp. 503-509.
|Titolo:||Pharmacokinetics, intraoperative effect and postoperative analgesia of tramadol in cats|
CAGNARDI, PETRA PICO' (Primo)
VILLA, ROBERTO EDOARDO (Secondo)
FONDA, DIEGO (Penultimo)
RAVASIO, GIULIANO (Ultimo)
|Parole Chiave:||pharmacokinetics; clinical efficacy; tramadol; cat|
|Settore Scientifico Disciplinare:||Settore VET/07 - Farmacologia e Tossicologia Veterinaria|
Settore VET/09 - Clinica Chirurgica Veterinaria
Settore VET/10 - Clinica Ostetrica e Ginecologia Veterinaria
|Data di pubblicazione:||giu-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.rvsc.2010.07.015|
|Appare nelle tipologie:||01 - Articolo su periodico|