Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.

Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy / M. Clerici, M. Saresella, D. Trabattoni, P. Ferrante, A. Vanzulli, A. Viganò. - In: AIDS. - ISSN 0269-9370. - 16:16(2002 Nov), pp. 2219-2221.

Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy

M. Clerici;D. Trabattoni;P. Ferrante;A. Vanzulli;
2002

Abstract

Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/156659
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