Highly active antiretroviral therapy (HAART) suppresses viral replication and augments CD4 T cell counts. HAART-associated immune restoration is often difficult to predict. We verified whether increases in CD4 cells, and particularly in cells of the naive phenotype, would be associated in HAART-treated children with thymic volume. Long-term immune reconstitution is significantly better in children with bigger thymuses at the initiation of HAART. Thymic volume has a strong predictive value for the immunological effect of HAART.
|Titolo:||Thymic volume predicts long-term immune reconstitution in HIV-infected children treated with highly active antiretroviral therapy|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||nov-2002|
|Digital Object Identifier (DOI):||10.1097/00002030-200211080-00015|
|Appare nelle tipologie:||01 - Articolo su periodico|