The antiviral effect (AVE) and interferon neutralizing capacity (INC) of sera originating from either seronegative or HIV-infected individuals were determined. As a rule, sera from seropositive subjects exhibited higher AVE titers than sera from seronegative individuals. Similarly, the INC of sera from HIV-infected patients, was most often stronger than that of sera from seronegative individuals. Furthermore, sera from HIV-infected patients actively immunized with i-IFN alpha invariably expressed INC in response to treatment, which was not the case for sera from control unimmunized patients. All sera from HIV-infected patients were found by ELISA to contain antibodies specifically directed to IFN alpha
Evidence for an antiviral effect and interferon neutralizing capacity in human sera : variability and implications for HIV infection / L. S. Fall, V. Chams, H. Le Coq, M. Fouchard, J.P. M'Bika, A. Gringeri, E. Santagostino, B. Bizzini. - In: CELLULAR AND MOLECULAR BIOLOGY. - ISSN 0145-5680. - 41:3(1995 May), pp. 409-416.
Evidence for an antiviral effect and interferon neutralizing capacity in human sera : variability and implications for HIV infection
A. Gringeri;
1995
Abstract
The antiviral effect (AVE) and interferon neutralizing capacity (INC) of sera originating from either seronegative or HIV-infected individuals were determined. As a rule, sera from seropositive subjects exhibited higher AVE titers than sera from seronegative individuals. Similarly, the INC of sera from HIV-infected patients, was most often stronger than that of sera from seronegative individuals. Furthermore, sera from HIV-infected patients actively immunized with i-IFN alpha invariably expressed INC in response to treatment, which was not the case for sera from control unimmunized patients. All sera from HIV-infected patients were found by ELISA to contain antibodies specifically directed to IFN alpha
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