The title compounds were obtained by reaction of conjugated azoalkenes with activated methinic derivatives bearing a propargylic residue. 1-Ureido-3-propargyl-2,3-dihydropyrrol-2-ols gave in the presence of Cu(I) catalyst the 2,5-dimethyl-3-ethoxycarbonyl-4-(2-oxopropyl)-1-(N'-phenylureido)-pyrr ole, while in the presence of Pd(0) or Au3+ the 3,6-dimethyl-5-ethoxycarbonyl-4-propargyl-1,4-dihydropyridazine was obtained by ring opening and ring expansion reaction. The propargylic side chain of 1-ureido-3-propargylpyrroles and 1-ureido-3-propargyl-3-phosphone-1H-pyrrol-2(3H)-ones was functionalised by means of palladium and/or copper catalysed coupling reactions with aryl or vinyl triflates and halides.
|Titolo:||Synthesis and transition metal catalysed reactionsnext term of 1-Ureido-3-propargyl-2,3-dihydropyrrol-2-ols, 1-ureido-3-propargylpyrroles and 1-ureido-3-propargyl-3-phosphono-1H-pyrrol-2(3H)-ones|
ROSSI, ELISABETTA (Penultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||1996|
|Digital Object Identifier (DOI):||10.1016/S0040-4020(96)00064-6|
|Appare nelle tipologie:||01 - Articolo su periodico|