Early development of immunity after hepatitis B vaccination is particularly important for patients such as hemophiliacs, at high risk for acquiring hepatitis B from potentially infectious plasma-derived concentrates. The purpose of this study was to evaluate whether or not protective antibody titers could be achieved quickly and maintained in hemophiliacs by an accelerated vaccination schedule. A yeast-recombinant hepatitis B vaccine (Engerix B, SKF Ritt) was given subcutaneously in the deltoid region and repeated 2 and 6 weeks later to 85 hemophiliacs negative for hepatitis B virus (HBV) markers. After the first 22 patients had been enrolled, a modification of the schedule involving a fourth booster dose 24 weeks after the first dose of vaccine was applied to the next 63 consecutive vaccines. Fifty-three percent of vaccinees had antibody titers to hepatitis B surface antigen (anti-HBs > or = 10 mlU/ml) by week 6, even though the mean titers of anti-HBs were somewhat lower than those achieved historically in normal individuals. The protection rate had increased to 87% by week 10, one month after the third dose of vaccine, and to 93% by week 24. One year after starting vaccination, the rate for the vaccinees who did not receive the fourth booster dose was 71%, and 96% for those who did receive the fourth dose, with only 2 patients not responding despite the booster dose. It is concluded that even though the accelerated schedule of immunization produced rapidly high rates of protective antibody titers, a booster dose is required to obtain higher titers and provide more persistent immunity
Accelerated schedule of hepatitis B vaccination in patients with hemophilia / E. Santagostino, P. M. Mannucci, A. Gringeri, M. Rumi, D. Rafanelli, A. Rocino, M. Schiavoni, A. Chistolini, E. Di Bona, G. Muleo. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 41:2(1993 Oct), pp. 95-98.
|Titolo:||Accelerated schedule of hepatitis B vaccination in patients with hemophilia|
|Parole Chiave:||HBV ; vaccine ; hemophiliacs ; protection|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||ott-1993|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jmv.1890410202|
|Appare nelle tipologie:||01 - Articolo su periodico|