3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones 2, readily available through Pd-catalyzed carbonylative coupling of 5-methyl-3-[2-(trimethylsilyl)ethynyl]pyridine-2-ylamine (1) with aryl iodides in the presence of carbon monoxide, undergo a domino conjugate addition/annulation reaction to give 4-hetero-substituted 2-aryl[1,8]naphthyridines 3 in high yields.
An efficient synthesis of 2,4-substituted [1,8]naphthyridines from 3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones / G. Abbiati, A. Arcadi, F. Marinelli, E. Rossi. - In: SYNTHESIS. - ISSN 0039-7881. - 2002:13(2002 Sep), pp. 1912-1916.
An efficient synthesis of 2,4-substituted [1,8]naphthyridines from 3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones
G. Abbiati;E. Rossi
2002
Abstract
3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones 2, readily available through Pd-catalyzed carbonylative coupling of 5-methyl-3-[2-(trimethylsilyl)ethynyl]pyridine-2-ylamine (1) with aryl iodides in the presence of carbon monoxide, undergo a domino conjugate addition/annulation reaction to give 4-hetero-substituted 2-aryl[1,8]naphthyridines 3 in high yields.
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