Aim: To assess the association between changes in plasma long-chain polyunsaturated fatty acids (LCPUFAs) profile and metabolic outcomes after 1-year nutritional intervention in normolipidaemic obese children. Methods: Fifty-seven normolipidaemic obese children, aged 8-13 years, were recruited in the study. Body mass index (BMI) z-scores were calculated. Fasting blood samples were analysed for insulin, glucose, lipid profile and fatty acid (FA) levels at baseline and after an 1-year nutritional-behaviour intervention. Insulin resistance was estimated by homeostatic model assessment (HOMA). Results: Fifty-one obese children completed the study. At the end of the intervention, the children showed decreased BMI z-score (mean reduction 0.25; 95% confidence interval [CI], 0.18-0.31), HOMA index (1.6; 0.6-2.5), plasma-saturated FA (1.49; 0.67-2.31 mg/ dL), C20:3n-9 (0.05; 0.02-0.07 mg/ dL) and increased plasma levels of monounsaturated FA (mean increase 1.35; 0.63-2.07 mg/ dL), n-6 PUFA (1.02; 0.08-1.97 mg/ dL), n-3 PUFA (0.24; 0.07-0.40 mg/ dL), C20:4n-6 (0.37; 0.11-0.63 mg/ dL), C18:3n-3 (0.04; 0.01-0.07 mg/ dL), C22:6n-3 (0.30; 0.17-0.42 mg/ dL) and the C22:6n-3 / C20:4n-6 ratio (0.02; 0.01-0.03 mg/ dL) ratio. Conclusions: Nutritional interventions may improve plasma LCPUFA profile and metabolic outcomes of normolipidaemic obese children.
Plasma long-chain fatty acids profile and metabolic outcomes in normolipidaemic obese children after one-year nutritional intervention / E. Verduci, G. Radaelli, M. Salvioni, E. Riva, M. Giovannini. - In: ACTA PAEDIATRICA. - ISSN 0803-5253. - 100:4(2011), pp. 585-589.
|Titolo:||Plasma long-chain fatty acids profile and metabolic outcomes in normolipidaemic obese children after one-year nutritional intervention|
VERDUCI, ELVIRA (Primo)
RIVA, ENRICA LICIA (Penultimo)
GIOVANNINI, MARCELLO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1651-2227.2010.02120.x|
|Appare nelle tipologie:||01 - Articolo su periodico|