Aim: To assess the association between changes in plasma long-chain polyunsaturated fatty acids (LCPUFAs) profile and metabolic outcomes after 1-year nutritional intervention in normolipidaemic obese children. Methods: Fifty-seven normolipidaemic obese children, aged 8-13 years, were recruited in the study. Body mass index (BMI) z-scores were calculated. Fasting blood samples were analysed for insulin, glucose, lipid profile and fatty acid (FA) levels at baseline and after an 1-year nutritional-behaviour intervention. Insulin resistance was estimated by homeostatic model assessment (HOMA). Results: Fifty-one obese children completed the study. At the end of the intervention, the children showed decreased BMI z-score (mean reduction 0.25; 95% confidence interval [CI], 0.18-0.31), HOMA index (1.6; 0.6-2.5), plasma-saturated FA (1.49; 0.67-2.31 mg/ dL), C20:3n-9 (0.05; 0.02-0.07 mg/ dL) and increased plasma levels of monounsaturated FA (mean increase 1.35; 0.63-2.07 mg/ dL), n-6 PUFA (1.02; 0.08-1.97 mg/ dL), n-3 PUFA (0.24; 0.07-0.40 mg/ dL), C20:4n-6 (0.37; 0.11-0.63 mg/ dL), C18:3n-3 (0.04; 0.01-0.07 mg/ dL), C22:6n-3 (0.30; 0.17-0.42 mg/ dL) and the C22:6n-3 / C20:4n-6 ratio (0.02; 0.01-0.03 mg/ dL) ratio. Conclusions: Nutritional interventions may improve plasma LCPUFA profile and metabolic outcomes of normolipidaemic obese children.

Plasma long-chain fatty acids profile and metabolic outcomes in normolipidaemic obese children after one-year nutritional intervention / E. Verduci, G. Radaelli, M. Salvioni, E. Riva, M. Giovannini. - In: ACTA PAEDIATRICA. - ISSN 0803-5253. - 100:4(2011), pp. 585-589. [10.1111/j.1651-2227.2010.02120.x]

Plasma long-chain fatty acids profile and metabolic outcomes in normolipidaemic obese children after one-year nutritional intervention

E. Verduci
Primo
;
M. Salvioni;E. Riva
Penultimo
;
M. Giovannini
Ultimo
2011

Abstract

Aim: To assess the association between changes in plasma long-chain polyunsaturated fatty acids (LCPUFAs) profile and metabolic outcomes after 1-year nutritional intervention in normolipidaemic obese children. Methods: Fifty-seven normolipidaemic obese children, aged 8-13 years, were recruited in the study. Body mass index (BMI) z-scores were calculated. Fasting blood samples were analysed for insulin, glucose, lipid profile and fatty acid (FA) levels at baseline and after an 1-year nutritional-behaviour intervention. Insulin resistance was estimated by homeostatic model assessment (HOMA). Results: Fifty-one obese children completed the study. At the end of the intervention, the children showed decreased BMI z-score (mean reduction 0.25; 95% confidence interval [CI], 0.18-0.31), HOMA index (1.6; 0.6-2.5), plasma-saturated FA (1.49; 0.67-2.31 mg/ dL), C20:3n-9 (0.05; 0.02-0.07 mg/ dL) and increased plasma levels of monounsaturated FA (mean increase 1.35; 0.63-2.07 mg/ dL), n-6 PUFA (1.02; 0.08-1.97 mg/ dL), n-3 PUFA (0.24; 0.07-0.40 mg/ dL), C20:4n-6 (0.37; 0.11-0.63 mg/ dL), C18:3n-3 (0.04; 0.01-0.07 mg/ dL), C22:6n-3 (0.30; 0.17-0.42 mg/ dL) and the C22:6n-3 / C20:4n-6 ratio (0.02; 0.01-0.03 mg/ dL) ratio. Conclusions: Nutritional interventions may improve plasma LCPUFA profile and metabolic outcomes of normolipidaemic obese children.
Settore MED/38 - Pediatria Generale e Specialistica
2011
Article (author)
File in questo prodotto:
File Dimensione Formato  
Verduci_et_al-2011-Acta_Paediatrica.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 102.99 kB
Formato Adobe PDF
102.99 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/155831
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 9
social impact