Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.
Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes / L. Rizzi, M. Braschi, M. Colombo, N. Vaiana, G. Tibolla, G.D. Norata, A. Catapano, S. Romeo, D. Prosperi. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 9:8(2011 Apr 21), pp. 2899-2905.
Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes
L. RizziPrimo
;N. Vaiana;G.D. Norata;A. Catapano;S. RomeoPenultimo
;
2011
Abstract
Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.
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