BACKGROUND: The authors investigated whether early stage lung cancer could be identified by proteomic analyses of plasma. METHODS: For the first case-control study, plasma samples from 52 patients with lung cancer and from a group of 51 controls were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. In a second case-control study, a classifier of 4 markers (mass-to-charge ratio, 11,681, 6843, 5607, and 8762) also was tested for validation on plasma from 16 consecutive patients with screen-detected cancer versus 406 healthy individuals. The most relevant marker was identified, and an enzyme-linked immunosorbent assay-based analysis revealed that signal intensity was correlated with concentration. RESULTS: The classifier had a sensitivity of 94.23% and a specificity of 76.47% in the first study but lost predictive value in the second study. Nevertheless, the 11,681 cluster, which was identified as serum amyloid protein A (SAA), resulted in a multiple logistic regression model that indicated a strong association with lung cancer. When both studies were considered as a together, the odds ratio (OR) for an SAA intensity ≥0.5 was 10.27 (95% confidence interval [CI], 4.64-22.74), whereas an analysis restricted to stage I cancers (TNM classification) revealed an OR of 8.45 (95% CI, 2.76-25.83) for T1 lung cancer and 21.22 (95% CI, 5.62-80.14) for T2 lung cancer. CONCLUSIONS: SAA levels were predictive of an elevated risk of lung cancer, supporting the general view that inflammation is implicated in lung cancer development.
Elevated levels of the acute-phase serum amyloid A are associated with heightened lung cancer risk / M. Cremona, E. Calabrò, G. Randi, M. De Bortoli, P. Mondellini, C. Verri, G. Sozzi, M.A. Pierotti, C. La Vecchia, U. Pastorino, I. Bongarzone. - In: CANCER. - ISSN 0008-543X. - 116:5(2010), pp. 1326-1335.
|Titolo:||Elevated levels of the acute-phase serum amyloid A are associated with heightened lung cancer risk|
|Parole Chiave:||Biomarkers; Epidemiologic study; Inflammation; Lung cancer risk; Serum amyloid A|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/cncr.24868|
|Appare nelle tipologie:||01 - Articolo su periodico|