A five-step synthesis of novel tricyclic beta-lactams has been exploited by stereoselective intramolecular cycloadditions of appropriate nitrilimines 6 and 12 These labile intermediates were generated in situ from the corresponding hydrazonoyl chlorides giving rise to the hitherto unknown azeto[3' 4' 1 2]hexano[34-c]pyrazole and azeto[3' 4' 1 2]heptano[3 4-c]pyrazole skeletons (C) 2010 Elsevier Ltd All rights reserved
Intramolecular nitrilimine cycloadditions onto beta-lactams bearing an alkenyl dipolarophile : synthesis of novel tricyclic beta-lactams / P. Del Buttero, G. Molteni, T. Pilati. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 21:21-22(2010 Nov 25), pp. 2603-2606. [10.1016/j.tetasy.2010.10.017]
Intramolecular nitrilimine cycloadditions onto beta-lactams bearing an alkenyl dipolarophile : synthesis of novel tricyclic beta-lactams
P. Del Buttero;G. Molteni;
2010
Abstract
A five-step synthesis of novel tricyclic beta-lactams has been exploited by stereoselective intramolecular cycloadditions of appropriate nitrilimines 6 and 12 These labile intermediates were generated in situ from the corresponding hydrazonoyl chlorides giving rise to the hitherto unknown azeto[3' 4' 1 2]hexano[34-c]pyrazole and azeto[3' 4' 1 2]heptano[3 4-c]pyrazole skeletons (C) 2010 Elsevier Ltd All rights reserved
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