Aim. The aim of this study was to evaluate the efficacy of pre-treatment with Serenoa repens (Permixon®) in reducing intra- and postoperative complications of surgical treatments of benign prostatic hyperplasia (BPH). Methods. A total of 144 patients with BPH, who were candidates for transurethral resection of the prostate (TURP) and open prostatectomy (OP), were admitted to the study and randomized to receive either a daily pre-treatment with 320 mg of Serenoa repens, Permixon® for two months prior to surgery (G1) or to undergo surgery without any pre-treatment (G2). Preoperative and postoperative courses were carefully monitored for each patient. Results. Of the 144 patients, 24 dropped out of the trial: 10 in G1 and 14 in G2. In G1, the duration of surgery was significantly shorter than in G2 (59.8 min vs. 77.6 min, respectively; P<0.001), no intraoperative complications were observed (0% vs. 15% in the control group; P=0.001) and transfusion needs were remarkably lower (0% in G1vs. 38.33% in G2; P<0.001). The postoperative course was significantly more favorable in G1 (with a shorter duration of catheterization, 64.95 h vs. 91.7 h in G2; P<0.001). There was also a significant change in hemodynamic parameters and the length of hospitalization was significantly shorter in the pretreated group (5.92 d in G1 vs. 7.92 d in G2; P<0.001). Conclusion. These data suggest that pre-treatment with Serenoa repens before surgery (TURP or OP) for BPH is effective in reducing intra- and postoperative complications.

Serenoa repens (Permixon) reduces intra- and postoperative complications of surgical treatments of benign prostatic hyperplasia / R. Anceschi, M. Bisi, N. Ghidini, G. Ferrari, P. Ferrari. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 0393-2249. - 62:3(2010), pp. 219-223.

Serenoa repens (Permixon) reduces intra- and postoperative complications of surgical treatments of benign prostatic hyperplasia

R. Anceschi;
2010

Abstract

Aim. The aim of this study was to evaluate the efficacy of pre-treatment with Serenoa repens (Permixon®) in reducing intra- and postoperative complications of surgical treatments of benign prostatic hyperplasia (BPH). Methods. A total of 144 patients with BPH, who were candidates for transurethral resection of the prostate (TURP) and open prostatectomy (OP), were admitted to the study and randomized to receive either a daily pre-treatment with 320 mg of Serenoa repens, Permixon® for two months prior to surgery (G1) or to undergo surgery without any pre-treatment (G2). Preoperative and postoperative courses were carefully monitored for each patient. Results. Of the 144 patients, 24 dropped out of the trial: 10 in G1 and 14 in G2. In G1, the duration of surgery was significantly shorter than in G2 (59.8 min vs. 77.6 min, respectively; P<0.001), no intraoperative complications were observed (0% vs. 15% in the control group; P=0.001) and transfusion needs were remarkably lower (0% in G1vs. 38.33% in G2; P<0.001). The postoperative course was significantly more favorable in G1 (with a shorter duration of catheterization, 64.95 h vs. 91.7 h in G2; P<0.001). There was also a significant change in hemodynamic parameters and the length of hospitalization was significantly shorter in the pretreated group (5.92 d in G1 vs. 7.92 d in G2; P<0.001). Conclusion. These data suggest that pre-treatment with Serenoa repens before surgery (TURP or OP) for BPH is effective in reducing intra- and postoperative complications.
Settore MED/24 - Urologia
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/154482
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 8
social impact