N-Cadherin has an important role during dendrite arborization, axon guidance, and synaptogenesis. In particular, at synaptic sites, N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity control. Recent studies have shown that N-cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that impairing ADAM10 localization and activity at synaptic sites decreases its processing of N-cadherin. This leads to an accumulation of the full-length form of N-cadherin, to an increase in spine head width, and to modifications of the number and function of glutamate receptors of AMPA type, both in vitro and in vivo. Our results indicate a key role for ADAM10 in the complex sequence of events through which N-cadherin affects spine maturation and controls structure and function of glutamatergic synapses

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage / M. Malinverno, M. Carta, R. Epis, E. Marcello, C. Verpelli, F. Cattabeni, C. Sala, C. Mulle, M. Di Luca, F. Gardoni. - In: THE JOURNAL OF NEUROSCIENCE. - ISSN 0270-6474. - 30:48(2010 Dec), pp. 16343-16355.

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage

M. Malinverno;R. Epis;E. Marcello;C. Verpelli;F. Cattabeni;M. Di Luca;F. Gardoni
2010

Abstract

N-Cadherin has an important role during dendrite arborization, axon guidance, and synaptogenesis. In particular, at synaptic sites, N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity control. Recent studies have shown that N-cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that impairing ADAM10 localization and activity at synaptic sites decreases its processing of N-cadherin. This leads to an accumulation of the full-length form of N-cadherin, to an increase in spine head width, and to modifications of the number and function of glutamate receptors of AMPA type, both in vitro and in vivo. Our results indicate a key role for ADAM10 in the complex sequence of events through which N-cadherin affects spine maturation and controls structure and function of glutamatergic synapses
Settore BIO/14 - Farmacologia
dic-2010
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/154340
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