The use of the palladium-catalyzed direct arylation was successfully tested on different electron-deficient heterocycles. The results demonstrate the effectiveness of the method based on the intramolecular coupling reaction providing polyazacyclic systems. This new application was obtained by using ligand-free conditions with the mixture of Pd(OAc)2 and TBAC as catalytic system. With suitable substrates different products arising from regioselective coupling were observed.
Efficient palladium-catalyzed direct arylation of azines and diazines using ligand- free conditions / L. Basolo, E.M. Beccalli, E. Borsini, G. Broggini. - In: TETRAHEDRON. - ISSN 0040-4020. - 65:17(2009), pp. 3486-3491.
Efficient palladium-catalyzed direct arylation of azines and diazines using ligand- free conditions
L. BasoloPrimo
;E.M. BeccalliSecondo
;
2009
Abstract
The use of the palladium-catalyzed direct arylation was successfully tested on different electron-deficient heterocycles. The results demonstrate the effectiveness of the method based on the intramolecular coupling reaction providing polyazacyclic systems. This new application was obtained by using ligand-free conditions with the mixture of Pd(OAc)2 and TBAC as catalytic system. With suitable substrates different products arising from regioselective coupling were observed.
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