Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2 -/- mice by transient mimicking of pre-TCR signals.
|Titolo:||Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
|Data di pubblicazione:||1-lug-2006|
|Digital Object Identifier (DOI):||10.1182/blood-2006-01-0143|
|Appare nelle tipologie:||01 - Articolo su periodico|