Chronic liver disease is characterized by a global hemostatic defect including platelet-vessel wall interaction (primary hemostasis), coagulation and fibrinolysis that may cause abnormalities of the relevant laboratory tests. The causal relationship between abnormal tests and bleeding has been widely accepted, despite the fact that abnormal tests are poorly associated with the timing and incidence of actual bleeding. In this article, we review recent evidence from the literature that disputes the above paradigm, and opens new venues for laboratory/clinical research and patient management in this field.
Abnormalities of hemostasis and bleeding in chronic liver disease : the paradigm is challenged / A. Tripodi, M. Primignani, P. M. Mannucci. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 5:1(2010 Feb), pp. 7-12.
Titolo: | Abnormalities of hemostasis and bleeding in chronic liver disease : the paradigm is challenged |
Autori: | TRIPODI, ARMANDO (Primo) MANNUCCI, PIER MANNUCCIO (Ultimo) |
Parole Chiave: | Acquired coagulation disorders; APTT; Cirrhosis; PT; Thrombin generation |
Settore Scientifico Disciplinare: | Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica |
Data di pubblicazione: | feb-2010 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s11739-009-0302-z |
Appare nelle tipologie: | 01 - Articolo su periodico |