In the absence of an effective vaccine against HIV, it is urgent to develop an effective alternative such as a microbicide. Single and repeated applications of MC1220 microbicide were evaluated in macaques. First, animals were given a single application of 0.5% or 1.5% MC1220-containing liposomal gel. A second group were treated with 0.5% MC1220 once a day for 4 days. The control groups were treated by liposomal gel alone. Thirty minutes after the last application, animals were challenged with RT-SHIV. In the first protocol, 2 of 4 animals treated by 0.5% of the MC1220 and 2 of 5 treated by 1.5% were protected. In the second protocol, 3 of 5 treated animals were protected and 5 of 5 controls were infected. The RNA viral load at necropsy was significantly lower (p = 0.05) in treated-infected animals than in controls. In both protocols, the number of CD4+ T cells was lower at viremia peak in infected than in protected animals.
Protective properties of non-nucleoside reverse transciptase inhibitor (MC1220) incorporated into liposome against intravaginal challenge of Rhesus Macaques with RT SHIV / M. Caron, G. Besson, S. Lekana-Douki Etenna, A. Mintsa-Ndong, S. Mourtas, A. Radaelli, C. De Giuli Morghen, R. Loddo, P. La Colla, S.G. Antimisiaris, M. Kazanji. - In: VIROLOGY. - ISSN 0042-6822. - 405:1(2010 Jun), pp. 225-233. [10.1016/j.virol.2010.06.008]
Protective properties of non-nucleoside reverse transciptase inhibitor (MC1220) incorporated into liposome against intravaginal challenge of Rhesus Macaques with RT SHIV
A. Radaelli;C. De Giuli Morghen;
2010
Abstract
In the absence of an effective vaccine against HIV, it is urgent to develop an effective alternative such as a microbicide. Single and repeated applications of MC1220 microbicide were evaluated in macaques. First, animals were given a single application of 0.5% or 1.5% MC1220-containing liposomal gel. A second group were treated with 0.5% MC1220 once a day for 4 days. The control groups were treated by liposomal gel alone. Thirty minutes after the last application, animals were challenged with RT-SHIV. In the first protocol, 2 of 4 animals treated by 0.5% of the MC1220 and 2 of 5 treated by 1.5% were protected. In the second protocol, 3 of 5 treated animals were protected and 5 of 5 controls were infected. The RNA viral load at necropsy was significantly lower (p = 0.05) in treated-infected animals than in controls. In both protocols, the number of CD4+ T cells was lower at viremia peak in infected than in protected animals.Pubblicazioni consigliate
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