Background: The potential clinical implications of autoimmunity during treatment with infliximab are unclear. Aim: To determine the frequency and correlation of autoantibody formation in patients with Crohn's disease treated with infliximab in a routine clinical setting. Methods: Sixty-three patients with refractory/inflammatory (31) and/or fistulising Crohn's disease (32), received an infliximab infusion at a dose 5 mg/kg in weeks O, 2 and 6, and were evaluated for the development of antinuclear, anti-double-stranded DNA, anti-Sm, anti-RNP, anti-SSA, anti-SSB and antihistone antibodies. The correlates with pharmacological treatments, the response to infliximab and adverse events were evaluated. Results: Antinuclear antibodies were found in five of the 63 patients (8%) at baseline and in 26 (42%) after 10 weeks (P < 0.001). Of the 26 antinuclear antibody-positive patients who were further subtyped, nine of 63 (17%) had anti-double-stranded DNA (P = 0.003), and 1.5% were extractable nuclear antigen (ENA) and antihistone-positive. Five patients were initially positive for anticardiolipin antibodies and two more patients became positive during infliximab treatment. New autoantibody formation was more frequent in the patients with inflammatory/refractory disease than in those with fistulising disease (17 vs. 7; P = 0.02). One patient developed drug-induced lupus without major organ damage. Conclusions: Autoantibody formation occurs in 42% of patients (8% of these patients were positive before infliximab treatment) with Crohn's disease receiving induction treatment with infliximab, but the clinical significance of this remains to be determined. (copyright) 2005 Blackwell Publishing Ltd.
Autoantibody profile during short-term infliximab treatment for Crohn's disease : a prospective cohort study / F. Atzeni, S. Ardizzone, P. Sarzi-Puttini, E. Colombo, G. Maconi, S. De Portu, M. Carrabba, G. Bianchi Porro. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - 22:5(2005), pp. 453-461.
|Titolo:||Autoantibody profile during short-term infliximab treatment for Crohn's disease : a prospective cohort study|
|Parole Chiave:||Crohn disease; abdominal abscess; adolescent; adult; aged; antibody production; antibody titer; arthralgia; article; autoimmune disease; autoimmunity; cohort analysis; controlled study; demography; drug response; drug safety; female; human; injection site reaction; intestine obstruction; liver abscess; lupus erythematosus; major clinical study; male; pneumonia; priority journal; DNA antibody; La antibody; Ro antibody; Sm antibody; amoxicillin plus clavulanic acid; antinuclear antibody; autoantibody; cardiolipin antibody; double stranded DNA; histone antibody; infliximab; ribonucleoprotein antibody; remicade|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1365-2036.2005.02576.x|
|Appare nelle tipologie:||01 - Articolo su periodico|