Spiro-beta-lactams were syntetized by means of the "Staudinger ketene-imine" reaction between non-symmetrical bisobstituted cyclic ketenes, generated from N-acyl-1,3-thiazolidine-2-carboxilic acids, and imines. The opening of the 1,3-thiazolidine ring was studied obtaining azetidine-2,3-diones. Antibacterial activity of spiro-beta-lactams were tested.
Sintesi di beta-lattami a potenziale attività farmacologica / G. Cremonesi ; tutor: Concetta La Rosa ; coordinatore: Carlo De Micheli. ISTITUTO DI CHIMICA ORGANICA "ALESSANDRO MARCHESINI", 2005 Dec. 18. ciclo, Anno Accademico 2004/2005.
Sintesi di beta-lattami a potenziale attività farmacologica
G. Cremonesi
2005
Abstract
Spiro-beta-lactams were syntetized by means of the "Staudinger ketene-imine" reaction between non-symmetrical bisobstituted cyclic ketenes, generated from N-acyl-1,3-thiazolidine-2-carboxilic acids, and imines. The opening of the 1,3-thiazolidine ring was studied obtaining azetidine-2,3-diones. Antibacterial activity of spiro-beta-lactams were tested.
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