Abstract of the PhD thesis entitled “Oral delivery systems intended for colonic release of insulin and selected functional adjuvants” Colon delivery has gained increased attention as a potential approach to improve the oral bioavailability of peptides and proteins. In this respect, the suitability of a previously developed release platform (ChronotopicTM) was explored for the conveyance of insulin and selected functional adjuvants. The system consists of a drug core and a swellable/erodible hydroxypropyl methylcellulose (HPMC) release-controlling coating. When an outer enteric film is applied, colon delivery is obtained based on relatively consistent small intestinal transit time. Preliminarily, the compatibility of insulin with a protease inhibitor (camostat mesilate, CM) and an absorption enhancer (sodium glycocholate, NaGly) was assessed. Subsequently, differing insulin/adjuvants release patterns were pursued by properly modifying the system formulation. A concurrent liberation of these compounds was achieved after reproducible and programmable lag phases from devices in which the protein and enzyme inhibitor/absorption enhancer were included in the core unit. The possibility of timing the adjuvant release to occur prior to that of the protein, which might allow a more favorable environment to be established in advance, was then investigated. For this purpose, prototypes with a CM/NaGly interlayer enclosed between HPMC coatings with differing thicknesses were prepared that elicited flexible two-pulse release profiles.
|Titolo:||ORAL DELIVERY SYSTEMS INTENDED FOR COLONIC RELEASE OF INSULIN AND SELECTED FUNCTIONAL ADJUVANTS|
|Supervisori e coordinatori interni:||DE MICHELI, CARLO|
|Data di pubblicazione:||17-dic-2009|
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Citazione:||ORAL DELIVERY SYSTEMS INTENDED FOR COLONIC RELEASE OF INSULIN AND SELECTED FUNCTIONAL ADJUVANTS ; tutor: Alessandra Maroni ; coordinatore: Carlo De Micheli. - Milano : Università degli studi di Milano. DIPARTIMENTO DI SCIENZE FARMACEUTICHE "PIETRO PRATESI", 2009 Dec 17. ((22. ciclo, Anno Accademico 2008/2009.|
|Appare nelle tipologie:||13 - Tesi di dottorato discussa entro ottobre 2010|