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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishBackground : thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) is successfully used in acute myocardial infarction with ST elevation (STEMI). Reocclusions follow rt-PA treatment in up to 30% of patients within one year. The infusion of rt-PA may induce the production of anti-t-PA antibodies which could interfere with the function of the native t-PA molecule. Methods : in order to detect and characterise anti-t-PA antibodies, plasma samples were collected from 30 STEMI patients (20 treated and 10 not treated with rt-PA) at baseline before rt-PA infusion and then 15, 30, 90 and 180 days after STEMI and from 40 healthy subjects at baseline only. Immunoenzymatic, chromatographic and chromogenic methods were employed. Results : an increase of anti-t-PA antibodies was observed 15 days (IgM, p=0.0001) and 30 days (IgG, p=0.0001) after rt-PA infusion. Six patients had large increases of anti-t-PA IgG which bound the catalytic domain of t-PA (two cases) or kringle 2 domain (four cases), were of IgG1 or IgG3 subclasses and interacted with the t-PA molecule in fluid phase. Conclusion : the infusion of rt-PA may induce the production of specific antibodies that bind active sites of t-PA, thus potentially reducing its in vivo function
Anti-t-PA antibodies in acute myocardial infarction after thrombolysis with rt-PA / M. Cugno, R. Castelli, G. Bisiani, S. Griffini, P. L. Meroni. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - 21:1(2010 Feb), pp. 25-29. [10.1016/j.ejim.2009.09.011]
| Titolo: | Anti-t-PA antibodies in acute myocardial infarction after thrombolysis with rt-PA | |
| Autori: | ||
| Parole Chiave: | Acute myocardial infarction; Antibodies; Reocclusion; Tissue-type plasminogen activator | |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna Settore MED/16 - Reumatologia | |
| Data di pubblicazione: | feb-2010 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ejim.2009.09.011 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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