Resistance to human immunodeficiency virus (HIV) infection in subjects who do not seroconvert despite multiple exposures to the virus and to the progression to AIDS in HIV-infected individuals depends on multiple factors involving both the innate and the adaptive immune system. The contribution of natural immunity in preventing HIV infection has so far received little attention, but many recently published articles suggest a key role for Toll-like receptors, natural killer cells, interleukin-22, acute-phase amyloid A protein, and APOBEC3G in conferring resistance to HIV infection. The study of these factors will shed light on HIV pathogenesis and contribute to the development of new therapeutic approaches to this elusive disease.
Innate immunity in resistance to HIV infection / M. Biasin, M.S. Clerici, L. Piacentini. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 202:suppl. 3(2010 Nov), pp. S361-S365.
|Titolo:||Innate immunity in resistance to HIV infection|
BIASIN, MARA (Primo)
CLERICI, MARIO SALVATORE (Secondo)
PIACENTINI, LUCA (Ultimo)
|Parole Chiave:||exposed uninfected individuals ; seronegative individuals ; cell-activation ; cutting edge ; NK ; responses ; virus ; expression ; protection|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||nov-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1086/655965|
|Appare nelle tipologie:||01 - Articolo su periodico|