Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (p(y) = 0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (p(y) = 0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.

KIRs and their HLA ligands in remitting-relapsing multiple sclerosis / C. Fusco, F.R. Guerini, G. Nocera, G. Ventrella, D. Caputo, M.A. Valentino, C. Agliardi, J. Gallotti, V.B. Morra, C. Florio, M.S. Clerici, M.L. Lombardi. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 229:1-2(2010 Dec 15), pp. 232-237.

KIRs and their HLA ligands in remitting-relapsing multiple sclerosis

C. Agliardi;M.S. Clerici;
2010-12-15

Abstract

Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (p(y) = 0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (p(y) = 0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.
natural-killer-cells ; immunoglobulin-like receptor ; experimental autoimmune encephalomyelitis ; T-cells ; class-I ; regulatory role ; NK cells ; disease ; genes ; susceptibility ; multiple sclerosis ; KIRs ; HLA-KIR ligands
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/152416
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