Angioedema due to hereditary C1 inhibitor deficiency (HAE) is a highly disabling and potentially lethal disease with an estimated prevalence of 1:50,000 in the general population worldwide. Treatment of this condition by replacing the deficient protein started shortly after discovery of the underlying genetic defect. Along with other therapeutic approaches developed over the years, C1 inhibitor replacement therapy maintains a central role for the treatment of angioedema attacks in patients with HAE. Two plasma-derived C1 inhibitors and a recombinant form, produced in transgenic rabbits, have successfully completed controlled trials that reinforced the evidence of the safety and efficacy of this treatment. Copyright

Replacement therapy with C1 esterase inhibitors for hereditary angioedema / M. Cicardi, A. Zanichelli. - In: DRUGS OF TODAY. - ISSN 1699-3993. - 46:11(2010), pp. 867-874.

Replacement therapy with C1 esterase inhibitors for hereditary angioedema

M. Cicardi
Primo
;
A. Zanichelli
Ultimo
2010

Abstract

Angioedema due to hereditary C1 inhibitor deficiency (HAE) is a highly disabling and potentially lethal disease with an estimated prevalence of 1:50,000 in the general population worldwide. Treatment of this condition by replacing the deficient protein started shortly after discovery of the underlying genetic defect. Along with other therapeutic approaches developed over the years, C1 inhibitor replacement therapy maintains a central role for the treatment of angioedema attacks in patients with HAE. Two plasma-derived C1 inhibitors and a recombinant form, produced in transgenic rabbits, have successfully completed controlled trials that reinforced the evidence of the safety and efficacy of this treatment. Copyright
Settore MED/09 - Medicina Interna
2010
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/151466
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