The application of a lactam enolate-pyridone addition sequence, originally developed for cytisine, has been applied successfully to generate the first examples of 4-halocytisines. Variation of the lactam component provides cyfusine and 4-fluorocyfusine.
Lactam Enolate-Pyridone Addition : Synthesis of 4-Halocytisines / P. Durkin, P. Magrone, S. Matthews, C. Dallanoce, T. Gallagher. - In: SYNLETT. - ISSN 0936-5214. - 2010:18(2010), pp. 2789-2791.
Lactam Enolate-Pyridone Addition : Synthesis of 4-Halocytisines
P. MagroneSecondo
;C. DallanocePenultimo
;
2010
Abstract
The application of a lactam enolate-pyridone addition sequence, originally developed for cytisine, has been applied successfully to generate the first examples of 4-halocytisines. Variation of the lactam component provides cyfusine and 4-fluorocyfusine.
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