A series of adenosine analogues differently substituted in N-6-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of H-1 NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.

N-6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity / R. Ottria, S. Casati, E. Baldoli, J.A.M. Maier, P. Ciuffreda. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 18:23(2010), pp. 8396-8402. [10.1016/j.bmc.2010.09.030]

N-6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity

R. Ottria
Primo
;
S. Casati
Secondo
;
E. Baldoli;J.A.M. Maier
Penultimo
;
P. Ciuffreda
Ultimo
2010

Abstract

A series of adenosine analogues differently substituted in N-6-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of H-1 NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.
Isopentenyladenosine ; cytokinins ; modified nucleosides; antitumor agents ; bladder carcinoma cells
Settore BIO/10 - Biochimica
Settore MED/04 - Patologia Generale
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/151165
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