3D numerical simulations of unipolar electrograms (EGs) and hybrid monophasic action potentials (HMAPs) were performed by using the cardiac Bidomain model with homogeneous and heterogeneous Luo–Rudy I membrane models. While estimating local recovery times from EGs can be difficult in case of flat T-waves or linear ST ramps, the HMAP signal always displays a monophasic downstroke as does the transmembrane action potential (TAP) and contains valuable information for assessing repolarization time. The simulation results show that: (a) the HMAP fast repolarization time is a reliable estimate of the TAP fast repolarization time; (b) the HMAP ending (90%) repolarization time is a less reliable estimate of the TAP ending repolarization time; (c) analogous conclusions hold for the associated action potential durations APD and APD90.

A Bidomain numerical validation for assessing times of fast and ending repolarization from monophasic action potentials / P. Colli Franzone, L.F. Pavarino, S. Scacchi, B. Taccardi - In: Progress in Industrial Mathematics at ECMI 2008 / [a cura di] A.D. Fitt, J. Norbury, H. Ockendon, E. Wilson. - 1st Edition. - Berlin : Springer, 2010. - ISBN 978-3-642-12109-8. - pp. 355-361 (( convegno ECMI 2008 tenutosi a London nel 2008 [10.1007/978-3-642-12110-4_54].

A Bidomain numerical validation for assessing times of fast and ending repolarization from monophasic action potentials

L.F. Pavarino
Secondo
;
S. Scacchi
Penultimo
;
2010

Abstract

3D numerical simulations of unipolar electrograms (EGs) and hybrid monophasic action potentials (HMAPs) were performed by using the cardiac Bidomain model with homogeneous and heterogeneous Luo–Rudy I membrane models. While estimating local recovery times from EGs can be difficult in case of flat T-waves or linear ST ramps, the HMAP signal always displays a monophasic downstroke as does the transmembrane action potential (TAP) and contains valuable information for assessing repolarization time. The simulation results show that: (a) the HMAP fast repolarization time is a reliable estimate of the TAP fast repolarization time; (b) the HMAP ending (90%) repolarization time is a less reliable estimate of the TAP ending repolarization time; (c) analogous conclusions hold for the associated action potential durations APD and APD90.
Settore MAT/08 - Analisi Numerica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/150574
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