Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide / C. Perrotta, E.G.I. Clementi. - In: PHYSIOLOGY. - ISSN 1548-9213. - 25:2(2010), pp. 64-71. [10.1152/physiol.00048.2009]
Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide
C. Perrotta;E.G.I. Clementi
2010
Abstract
Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
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