An efficient and versatile synthetic method relating to Ubiquinone or Menaquinone derivatives compound is disclosed, leading to final compounds with high isomeric purity in good overall yields. The technologic transfer of the method allowed to solve industrial concern about the production; the present method has been scaled up, offering the possibility for the synthesis to compete with natural fermentative sources of such compounds.
'INVESTIGATION OF NEW EFFICIENT SYNTHESIS OF UBIQUINONES, MENAQUINONES DERIVATIVES AND UBIDECARENONE; COMPARISON OF PROBLEMS IN THE SYNTHETIC AND ANALYTICAL ASPECTS OF RESEARCH AND SCALING UP' / D. Bianchi ; tutor: Ermanno Valoti ; coordinatore del dottorato: Carlo De Micheli. Universita' degli Studi di Milano, 2010 Dec 15. 23. ciclo, Anno Accademico 2010.
'INVESTIGATION OF NEW EFFICIENT SYNTHESIS OF UBIQUINONES, MENAQUINONES DERIVATIVES AND UBIDECARENONE; COMPARISON OF PROBLEMS IN THE SYNTHETIC AND ANALYTICAL ASPECTS OF RESEARCH AND SCALING UP'.
D. Bianchi
2010
Abstract
An efficient and versatile synthetic method relating to Ubiquinone or Menaquinone derivatives compound is disclosed, leading to final compounds with high isomeric purity in good overall yields. The technologic transfer of the method allowed to solve industrial concern about the production; the present method has been scaled up, offering the possibility for the synthesis to compete with natural fermentative sources of such compounds.
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