We assessed recent trends in hepatitis C virus (HCV) prevalence in pregnant women with HIV using data from a large national study. Based on 1240 pregnancies, we observed a 34-fold decline in HCV seroprevalence in pregnant women with HIV between 2001 (293%) and 2008 (86%). This decline was the net result of two components: a progressively declining HCV seroprevalence in non-African women (from 357% in 2001 to 167% in 2008), sustained by a parallel reduction in history of injecting drug use (IDU) in this population, and a significantly growing presence (from 212% in 2001 to 486% in 2008) of women of African origin, at very low risk of being HCV-infected [average HCV prevalence 1%, adjusted odds ratio (aOR) for HCV 009, 95% CI 003-029]. Previous IDU was the stronger determinant of HCV co-infection in pregnant women with HIV (aOR 309, 95% CI 188-511). The observed trend is expected to translate into a reduced number of cases of vertical HCV transmission. Copyright
Declining HCV seroprevalence in pregnant women with HIV / M. Floridia, E. Tamburrini, G. Anzidei, C. Tibaldi, M.L. Muggiasca, G. Guaraldi, M. Fiscon, A. Vimercati, P. Martinelli, A. Donisi, S. Dalzero, M. Ravizza, Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy. - In: EPIDEMIOLOGY AND INFECTION. - ISSN 0950-2688. - 138:9(2010 Sep), pp. 1317-1321. [10.1017/S0950268810000129]
Declining HCV seroprevalence in pregnant women with HIV
S. Dalzero;
2010
Abstract
We assessed recent trends in hepatitis C virus (HCV) prevalence in pregnant women with HIV using data from a large national study. Based on 1240 pregnancies, we observed a 34-fold decline in HCV seroprevalence in pregnant women with HIV between 2001 (293%) and 2008 (86%). This decline was the net result of two components: a progressively declining HCV seroprevalence in non-African women (from 357% in 2001 to 167% in 2008), sustained by a parallel reduction in history of injecting drug use (IDU) in this population, and a significantly growing presence (from 212% in 2001 to 486% in 2008) of women of African origin, at very low risk of being HCV-infected [average HCV prevalence 1%, adjusted odds ratio (aOR) for HCV 009, 95% CI 003-029]. Previous IDU was the stronger determinant of HCV co-infection in pregnant women with HIV (aOR 309, 95% CI 188-511). The observed trend is expected to translate into a reduced number of cases of vertical HCV transmission. Copyright
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