A novel class of coumarin-thiazole conjugated systems (1–31) were synthesized by Hantzsch condensation between a-bromo-3-acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates of H. pylori clinical strains,including four metronidazole resistant ones.
Synthesis and Anti-Helicobacter pylori Activity of 4-(Coumarin-3-yl)thiazol-2-ylhydrazone Derivatives / F. Chimenti, B. Bizzarri, A. Bolasco, D. Secci, P. Chimenti, A. Granese, S. Carradori, M. D’Ascenzio, M. M. Scaltrito, F. Sisto. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - 47:6(2010 Nov), pp. 1269-1274.
Synthesis and Anti-Helicobacter pylori Activity of 4-(Coumarin-3-yl)thiazol-2-ylhydrazone Derivatives
M. M. ScaltritoPenultimo
;F. SistoUltimo
2010
Abstract
A novel class of coumarin-thiazole conjugated systems (1–31) were synthesized by Hantzsch condensation between a-bromo-3-acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates of H. pylori clinical strains,including four metronidazole resistant ones.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.