Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.
Repairing skeletal muscle : regenerative potential of skeletal muscle stem cells / F.S. Tedesco, A. Dellavalle, J. Diaz-Manera, G. Messina, G. Cossu. - In: THE JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0021-9738. - 120:1(2010), pp. 11-19. [10.1172/JCI40373]
Repairing skeletal muscle : regenerative potential of skeletal muscle stem cells
G. MessinaPenultimo
;G. CossuUltimo
2010
Abstract
Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.File | Dimensione | Formato | |
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JCI 2010, Tedesco et al 2010.pdf
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