Background. CD133 is a member of a novel family of cell surface glycoproteins. Initially, the expression of CD133 antigen was seen only in the hematopoietic derived CD34+ stem cells. At present, CD133 expression is demonstrated in undifferentiated epithelium, different types of tumors and myogenic cells. CD133+ neurosphere cells isolated from brain are able to differentiate into both neurons and glial cells. These data suggested that CD133 could be a specific marker for various stem and progenitor cell populations. Objectives. The main goal would be to describe the role for CD133 as a marker of stem cells able to engraft and differentiate, to form functional non-hematopoietic adult lineages and contribute to disease amelioration via tissue regeneration. Results/conclusion. In conclusion, since the rise of CD133 antigen as a suitable stem cell marker, the possible use of CD133+ stem cells in therapeutic applications has opened a new promising field in the treatment of degenerating diseases. The human circulating cells expressing the CD133 antigen behave as a stem cell population capable of commitment to hematopoietic, endothelial and myogenic lineages. CD133 cell therapy may represent a promising treatment for many diseases.
CD133+ cells isolated from various sources and their role in future clinical perspective / M.A. Meregalli, A. Farini, M.L.C. Belicchi, Y. Torrente. - In: EXPERT OPINION ON BIOLOGICAL THERAPY. - ISSN 1471-2598. - 10:11(2010), pp. 1521-1528.
|Titolo:||CD133+ cells isolated from various sources and their role in future clinical perspective|
MEREGALLI, MIRELLA ANGELA (Primo)
FARINI, ANDREA (Secondo)
BELICCHI, MARZIA LAURA CHIARA (Penultimo)
TORRENTE, YVAN (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1517/14712598.2010.528386|
|Appare nelle tipologie:||01 - Articolo su periodico|